Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension

RATIONALE: Pulmonary vascular remodeling is key to the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH). We recently reported that fibroblast growth factor-2 (FGF2) is markedly overproduced by pulmonary-endothelial cells (P-ECs) in IPAH, and contributes significantly to smooth muscl...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Tu, Ly, Dewachter, Laurence, Gore, Benoit, Fadel, Elie, Dartevelle, Philippe, Simonneau, Gérald, Humbert, Marc, Eddahibi, Saadia, Guignabert, Christophe
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834126/
https://ncbi.nlm.nih.gov/pubmed/21037114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2010-0317OC
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