Annexin A2 Reduces PCSK9 Protein Levels via a Translational Mechanism and Interacts with the M1 and M2 Domains of PCSK9

Annexin A2 (AnxA2) was reported to be an extracellular endogenous inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) activity on cell-surface LDL receptor degradation. In this study, we investigated the effect of silencing the expression of AnxA2 and PCSK9 in HepG2 and Huh7 cells to...

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Detalhes bibliográficos
Main Authors: Ly, Kévin, Luna Saavedra, Yascara Grisel, Canuel, Maryssa, Routhier, Sophie, Desjardins, Roxane, Hamelin, Josée, Mayne, Janice, Lazure, Claude, Seidah, Nabil G., Day, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067207/
https://ncbi.nlm.nih.gov/pubmed/24808179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541094
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