The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth

Rap1 is a Ras family GTPase with a well documented role in ERK/MAP kinase signaling and integrin activation. Stimulation of the G-protein-coupled receptor PAR-1 with thrombin in human 1321N1 glioblastoma cells led to a robust increase in Rap1 activation. This response was sustained for up to 6 h and...

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Autores principales: Sayyah, Jacqueline, Bartakova, Alena, Nogal, Nekeisha, Quilliam, Lawrence A., Stupack, Dwayne G., Brown, Joan Heller
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067203/
https://ncbi.nlm.nih.gov/pubmed/24790104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536227
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