SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras

SHANK3, a synaptic scaffold protein and actin regulator, is widely expressed outside of the central nervous system with predominantly unknown function. Solving the structure of the SHANK3 N-terminal region revealed that the SPN-domain is an unexpected Ras-association domain with high affinity for GT...

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Veröffentlicht in:Nat Cell Biol
Hauptverfasser: Lilja, Johanna, Zacharchenko, Thomas, Georgiadou, Maria, Jacquemet, Guillaume, De Franceschi, Nicola, Peuhu, Emilia, Hamidi, Hellyeh, Pouwels, Jeroen, Martens, Victoria, Nia, Fatemeh Hassani, Beifuss, Malte, Boeckers, Tobias, Kreienkamp, Hans-Juergen, Barsukov, Igor L, Ivaska, Johanna
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386136/
https://ncbi.nlm.nih.gov/pubmed/28263956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3487
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