Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61

A subset of G-protein coupled receptors (GPCRs), including the thrombin receptor (PAR1), elicits mitogenic responses. Thrombin also activates Ras homolog gene family member A (RhoA) and activating protein (AP-1) -mediated gene expression in 1321N1 astrocytoma cells, whereas the nonmitogenic agonist...

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Detalhes bibliográficos
Main Authors: Walsh, Colin T., Radeff-Huang, Julie, Matteo, Rosalia, Hsiao, Albert, Subramaniam, Shankar, Stupack, Dwayne, Brown, Joan Heller
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2008
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980657/
https://ncbi.nlm.nih.gov/pubmed/18687805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-113266
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