Loss of Rassf1a synergises with deregulated Runx2 signaling in tumorigenesis

The tumor suppressor gene RASSF1A is inactivated through point mutation or promoter hypermethylation in many human cancers. In this study, we performed a Sleeping Beauty transposon-mediated insertional mutagenesis screen in Rassf1a null mice to identify candidate genes that collaborate with loss of...

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Bibliographic Details
Main Authors: van der Weyden, Louise, Papaspyropoulos, Angelos, Poulogiannis, George, Rust, Alistair G., Rashid, Mamunur, Adams, David J., Arends, Mark J., O’Neill, Eric
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067151/
https://ncbi.nlm.nih.gov/pubmed/22710434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3343
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