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The Ras-association domain family (RASSF) members and their role in human tumourigenesis
Ras proteins play a direct causal role in human cancer with activating mutations in Ras occurring in ∼ 30% of tumours. Ras effectors also contribute to cancer, as mutations occur in Ras effectors, notably B-Raf and PI3-K, and drugs blocking elements of these pathways are in clinical development. In...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier Pub. Co
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586335/ https://ncbi.nlm.nih.gov/pubmed/17692468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbcan.2007.06.003 |
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