Comparative Analysis of the Substrate Specificity of trans- versus cis-Acyltransferases of Assembly Line Polyketide Synthases

[Image: see text] Due to their pivotal role in extender unit selection during polyketide biosynthesis, acyltransferase (AT) domains are important engineering targets. A subset of assembly line polyketide synthases (PKSs) are serviced by discrete, trans-acting ATs. Theoretically, these trans-ATs can...

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Main Authors: Dunn, Briana J., Watts, Katharine R., Robbins, Thomas, Cane, David E., Khosla, Chaitan
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067149/
https://ncbi.nlm.nih.gov/pubmed/24871074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5004316
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