Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

BACKGROUND: The trimeric envelope glycoproteins (Env) on the surface of HIV-1 virions are the targets for neutralizing antibodies (NAbs). No candidate HIV-1 immunogen has yet induced potent, broadly active NAbs (bNAbs). Part of the explanation may be that previously tested Env proteins inadequately...

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Detalhes bibliográficos
Main Authors: Yasmeen, Anila, Ringe, Rajesh, Derking, Ronald, Cupo, Albert, Julien, Jean-Philippe, Burton, Dennis R, Ward, Andrew B, Wilson, Ian A, Sanders, Rogier W, Moore, John P, Klasse, Per Johan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067080/
https://ncbi.nlm.nih.gov/pubmed/24884783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-41
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