Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code

Aminoacyl-tRNA synthetases use a variety of mechanisms to ensure fidelity of the genetic code and ultimately select the correct amino acids to be used in protein synthesis. The physiological necessity of these quality control mechanisms in different environments remains unclear, as the cost vs benef...

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Bibliografiske detaljer
Main Authors: Bullwinkle, Tammy J, Reynolds, Noah M, Raina, Medha, Moghal, Adil, Matsa, Eleftheria, Rajkovic, Andrei, Kayadibi, Huseyin, Fazlollahi, Farbod, Ryan, Christopher, Howitz, Nathaniel, Faull, Kym F, Lazazzera, Beth A, Ibba, Michael
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2014
Fag:
Biochemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066437/
https://ncbi.nlm.nih.gov/pubmed/24891238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02501
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