Reduced Amino Acid Specificity of Mammalian Tyrosyl-tRNA Synthetase Is Associated with Elevated Mistranslation of Tyr Codons

Quality control operates at different steps in translation to limit errors to approximately one mistranslated codon per 10,000 codons during mRNA-directed protein synthesis. Recent studies have suggested that error rates may actually vary considerably during translation under different growth condit...

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Detalhes bibliográficos
Main Authors: Raina, Medha, Moghal, Adil, Kano, Amanda, Jerums, Mathew, Schnier, Paul D., Luo, Shun, Deshpande, Rohini, Bondarenko, Pavel V., Lin, Henry, Ibba, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067211/
https://ncbi.nlm.nih.gov/pubmed/24828507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.564609
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