Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice

Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol (DAG), a lipid that has been linked to the development of hepatic insulin resistance through activation of protein kinase C (PKC). The expression of genes that encode MGAT enzymes is induced in the livers of i...

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Bibliografiska uppgifter
Huvudupphovsmän: Hall, Angela M., Soufi, Nisreen, Chambers, Kari T., Chen, Zhouji, Schweitzer, George G., McCommis, Kyle S., Erion, Derek M., Graham, Mark J., Su, Xiong, Finck, Brian N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Diabetes Association 2014
Ämnen:
Metabolism
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066334/
https://ncbi.nlm.nih.gov/pubmed/24595352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1502
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