Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets

BACKGROUND: Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute t...

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Bibliographische Detailangaben
Hauptverfasser: Hall, Elin, Volkov, Petr, Dayeh, Tasnim, Bacos, Karl, Rönn, Tina, Nitert, Marloes Dekker, Ling, Charlotte
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065864/
https://ncbi.nlm.nih.gov/pubmed/24953961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-12-103
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