Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect disease susceptibility. To describe the human methylome in pancreatic islets and determine the epigenetic basis of T2D, we analyzed DNA methylation of 479,927 CpG sites and the transcriptome in pancreatic islet...

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Detalhes bibliográficos
Main Authors: Dayeh, Tasnim, Volkov, Petr, Salö, Sofia, Hall, Elin, Nilsson, Emma, Olsson, Anders H., Kirkpatrick, Clare L., Wollheim, Claes B., Eliasson, Lena, Rönn, Tina, Bacos, Karl, Ling, Charlotte
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945174/
https://ncbi.nlm.nih.gov/pubmed/24603685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004160
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