Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect disease susceptibility. To describe the human methylome in pancreatic islets and determine the epigenetic basis of T2D, we analyzed DNA methylation of 479,927 CpG sites and the transcriptome in pancreatic islet...

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Detaylı Bibliyografya
Asıl Yazarlar: Dayeh, Tasnim, Volkov, Petr, Salö, Sofia, Hall, Elin, Nilsson, Emma, Olsson, Anders H., Kirkpatrick, Clare L., Wollheim, Claes B., Eliasson, Lena, Rönn, Tina, Bacos, Karl, Ling, Charlotte
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945174/
https://ncbi.nlm.nih.gov/pubmed/24603685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004160
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