Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect disease susceptibility. To describe the human methylome in pancreatic islets and determine the epigenetic basis of T2D, we analyzed DNA methylation of 479,927 CpG sites and the transcriptome in pancreatic islet...

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Autori principali: Dayeh, Tasnim, Volkov, Petr, Salö, Sofia, Hall, Elin, Nilsson, Emma, Olsson, Anders H., Kirkpatrick, Clare L., Wollheim, Claes B., Eliasson, Lena, Rönn, Tina, Bacos, Karl, Ling, Charlotte
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945174/
https://ncbi.nlm.nih.gov/pubmed/24603685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004160
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