Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats

Nicotine-induced hypothermia is well established, but the nicotinic receptor actions underlying this effect are not clear. Nicotine causes activation and desensitization at a variety of nicotinic receptor subtypes. Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a nove...

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Autori principali: Rezvani, Amir H., Timofeeva, Olga, Sexton, Hannah G., DeCuir, Damien, Xiao, Yingxian, Gordon, Christopher J., Kellar, Kenneth J., Levin, Edward D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065797/
https://ncbi.nlm.nih.gov/pubmed/22387853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2012.02.031
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