Oral Sazetidine-A, a Selective α4β2* Nicotinic Receptor Desensitizing Agent, Reduces Nicotine Self-Administration in Rats

Sazetidine-A selectively desensitizes α4β2 nicotinic receptors and also has partial agonist effects. We have shown that subcutaneous acute and repeated injections as well as chronic infusions of sazetidine-A significantly reduce intravenous (IV) nicotine self-administration in rats. To further inves...

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Publicado en:Pharmacol Biochem Behav
Autores principales: Rezvani, Amir H, Wells, Corinne, Slade, Susan, Xiao, Yingxian, Kellar, Kenneth J, Levin, Edward D
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570822/
https://ncbi.nlm.nih.gov/pubmed/30794849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2019.02.007
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