Effects of sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats

RATIONALE: Manipulations of nicotinic cholinergic receptors have been shown to influence both alcohol and nicotine intake. Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a novel compound that potently and selectively desensitizes α4β2 nicotinic receptors with only mod...

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Autori principali: Rezvani, Amir H., Slade, Susan, Wells, Cori, Petro, Ann, Lumeng, Lawrence, Li, Ting-Kai, Xiao, Yingxian, Brown, Milton L., Paige, Mikell A., McDowell, Brian E., Rose, Jed E., Kellar, Kenneth J., Levin, Edward D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695635/
https://ncbi.nlm.nih.gov/pubmed/20535453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-010-1878-8
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