α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats

Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a selective α4β2 nicotinic receptor desensitizing agent and partial agonist. Sazetidine-A has been shown in our previous studies to significantly reduce nicotine and alcohol self-administration in rats. The question arise...

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Detalhes bibliográficos
Publicado no:Eur J Pharmacol
Main Authors: Levin, Edward D., Rezvani, Amir H., Wells, Corinne, Slade, Susan, Yenugonda, Venkata M., Liu, Yong, Brown, Milton L., Xiao, Yingxian, Kellar, Kenneth J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6353686/
https://ncbi.nlm.nih.gov/pubmed/30529197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2018.12.010
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