Chronic Sazetidine-A at Behaviorally Active Doses Does Not Increase Nicotinic Cholinergic Receptors in Rodent Brain

Chronic nicotine administration increases α4β2 neuronal nicotinic acetylcholine receptor (nAChR) density in brain. This up-regulation probably contributes to the development and/or maintenance of nicotine dependence. nAChR up-regulation is believed to be triggered at the ligand binding site, so it i...

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Hlavní autoři: Hussmann, G. Patrick, Turner, Jill R., Lomazzo, Ermelinda, Venkatesh, Rashmi, Cousins, Vanessa, Xiao, Yingxian, Yasuda, Robert P., Wolfe, Barry B., Perry, David C., Rezvani, Amir H., Levin, Edward D., Blendy, Julie A., Kellar, Kenneth J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2012
Témata:
Neuropharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477215/
https://ncbi.nlm.nih.gov/pubmed/22899752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.198085
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