Chronic Sazetidine-A at Behaviorally Active Doses Does Not Increase Nicotinic Cholinergic Receptors in Rodent Brain

Chronic nicotine administration increases α4β2 neuronal nicotinic acetylcholine receptor (nAChR) density in brain. This up-regulation probably contributes to the development and/or maintenance of nicotine dependence. nAChR up-regulation is believed to be triggered at the ligand binding site, so it i...

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Главные авторы: Hussmann, G. Patrick, Turner, Jill R., Lomazzo, Ermelinda, Venkatesh, Rashmi, Cousins, Vanessa, Xiao, Yingxian, Yasuda, Robert P., Wolfe, Barry B., Perry, David C., Rezvani, Amir H., Levin, Edward D., Blendy, Julie A., Kellar, Kenneth J.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2012
Предметы:
Neuropharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477215/
https://ncbi.nlm.nih.gov/pubmed/22899752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.198085
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