Chronic Sazetidine-A at Behaviorally Active Doses Does Not Increase Nicotinic Cholinergic Receptors in Rodent Brain

Chronic nicotine administration increases α4β2 neuronal nicotinic acetylcholine receptor (nAChR) density in brain. This up-regulation probably contributes to the development and/or maintenance of nicotine dependence. nAChR up-regulation is believed to be triggered at the ligand binding site, so it i...

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Detalhes bibliográficos
Main Authors: Hussmann, G. Patrick, Turner, Jill R., Lomazzo, Ermelinda, Venkatesh, Rashmi, Cousins, Vanessa, Xiao, Yingxian, Yasuda, Robert P., Wolfe, Barry B., Perry, David C., Rezvani, Amir H., Levin, Edward D., Blendy, Julie A., Kellar, Kenneth J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477215/
https://ncbi.nlm.nih.gov/pubmed/22899752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.198085
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