Chronic Sazetidine-A Maintains Anxiolytic Effects and Slower Weight Gain Following Chronic Nicotine Without Maintaining Increased Density of Nicotinic Receptors in Rodent Brain

Chronic nicotine administration increases the density of brain α4β2* nicotinic acetylcholine receptors (nAChRs), which may contribute to withdrawal symptoms associated with smoking cessation. Varenicline, a smoking cessation drug, also increases these receptors in rodent brain. The maintenance of th...

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Bibliographic Details
Main Authors: Hussmann, G. Patrick, DeDominicis, Kristen E., Turner, Jill R., Yasuda, Robert P., Klehm, Jacquelyn, Forcelli, Patrick A., Xiao, Yingxian, Richardson, Janell R., Sahibzada, Niaz, Wolfe, Barry B., Lindstrom, Jon, Blendy, Julie A., Kellar, Kenneth J.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999245/
https://ncbi.nlm.nih.gov/pubmed/24422997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12653
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