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Amyloid at the cutting edge: activation of α-secretase prevents amyloidogenesis in an Alzheimer disease mouse model
The amyloid β-peptide (Aβ peptide) is assumed to play a crucial and early role in the pathogenesis of Alzheimer disease. Thus, strategies for a pharmacotherapy aim at reducing Aβ peptide generation, which proteolytically derives from the amyloid precursor protein (APP). The main targets so far have...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC406534/ https://ncbi.nlm.nih.gov/pubmed/15146234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421746 |
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