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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of molecular, cellular, and animal models. Cholic acid (CA) prevents hepatic TG accumulation, VLDL secretion, and elevated serum TG in mouse models of hypertriglyceridemia. At the molecular level, CA decreases...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC406532/ https://ncbi.nlm.nih.gov/pubmed/15146238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421025 |
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