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Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity
Faithful maintenance and propagation of eukaryotic genomes is ensured by three-step DNA ligation reactions employed by ATP-dependent DNA ligases(1,2). Paradoxically, when DNA ligases encounter nicked DNA structures with abnormal DNA termini, DNA ligase catalytic activity can generate and/or exacerba...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4064939/ https://ncbi.nlm.nih.gov/pubmed/24362567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12824 |
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