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Structure of an Aprataxin–DNA complex with insights into AOA1 Neurodegenerative Disease
DNA ligases finalize DNA replication and repair through DNA nick-sealing reactions that can abort to generate cytotoxic 5′-adenylation DNA damage (5′-AMP). Aprataxin (Aptx) catalyses direct reversal of 5′-AMP adducts to protect genome integrity. Here, the structure of an Aptx-DNA-AMP-Zn complex reve...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3210380/ https://ncbi.nlm.nih.gov/pubmed/21984210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2146 |
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