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Recognition and repair of chemically heterogeneous structures at DNA ends

Exposure to environmental toxicants and stressors, radiation, pharmaceutical drugs, inflammation, cellular respiration, and routine DNA metabolism all lead to the production of cytotoxic DNA strand breaks. Akin to splintered wood, DNA breaks are not “clean”. Rather, DNA breaks typically lack DNA 5&#...

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Detalhes bibliográficos
Publicado no:Environ Mol Mutagen
Main Authors: Andres, Sara N., Schellenberg, Matthew J., Wallace, Bret D., Tumbale, Percy, Williams, R. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303525/
https://ncbi.nlm.nih.gov/pubmed/25111769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.21892
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