Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

To systematically investigate the impact of immune stimulation upon regulatory variant activity, we exposed primary monocytes from 432 healthy Europeans to interferon-γ (IFN-γ) or differing durations of lipopolysaccharide and mapped expression quantitative trait loci (eQTLs). More than half of cis-e...

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Hauptverfasser: Fairfax, Benjamin P., Humburg, Peter, Makino, Seiko, Naranbhai, Vivek, Wong, Daniel, Lau, Evelyn, Jostins, Luke, Plant, Katharine, Andrews, Robert, McGee, Chris, Knight, Julian C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064786/
https://ncbi.nlm.nih.gov/pubmed/24604202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1246949
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