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AltHapAlignR: improved accuracy of RNA-seq analyses through the use of alternative haplotypes

MOTIVATION: Reliance on mapping to a single reference haplotype currently limits accurate estimation of allele or haplotype-specific expression using RNA-sequencing, notably in highly polymorphic regions such as the major histocompatibility complex. RESULTS: We present AltHapAlignR, a method incorpo...

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Bibliografische gegevens
Gepubliceerd in:Bioinformatics
Hoofdauteurs: Lee, Wanseon, Plant, Katharine, Humburg, Peter, Knight, Julian C
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041798/
https://ncbi.nlm.nih.gov/pubmed/29514179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty125
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