Metabolic syndrome without obesity: Hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice

In obese humans and rodents there is increased expression of the key glucocorticoid (GC) regenerating enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), in adipose tissue. This increased expression appears to be of pathogenic importance because transgenic mice overexpressing 11β-HSD1 select...

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Main Authors: Paterson, Janice M., Morton, Nicholas M., Fievet, Catherine, Kenyon, Christopher J., Holmes, Megan C., Staels, Bart, Seckl, Jonathan R., Mullins, John J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC406470/
https://ncbi.nlm.nih.gov/pubmed/15118095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305524101
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