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Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor
Structurally diverse organophosphonate inhibitors targeting the active site of the enzyme were used to investigate the relationship of the active site and the dimer interface of wild-type protease in solution. Positional scanning synthetic combinatorial libraries revealed Kaposi's sarcoma-assoc...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC406434/ https://ncbi.nlm.nih.gov/pubmed/15118083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401613101 |
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