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Substrate modulation of enzyme activity in the herpesvirus protease family

The herpesvirus proteases are an example in which allosteric regulation of an enzyme activity is achieved through the formation of quaternary structure. Here, we report a 1.7 Å resolution structure of Kaposi’s Sarcoma herpesvirus protease in complex with a hexapeptide transition state analogue that...

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Autori principali: Lazic, Ana, Goetz, David H., Nomura, Anson M., Marnett, Alan B., Craik., Charles S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2078331/
https://ncbi.nlm.nih.gov/pubmed/17870089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.07.073
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