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Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases
[Image: see text] Herpesviruses rely on a homodimeric protease for viral capsid maturation. A small molecule, DD2, previously shown to disrupt dimerization of Kaposi’s sarcoma-associated herpesvirus protease (KSHV Pr) by trapping an inactive monomeric conformation and two analogues generated through...
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| Main Authors: | , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2014
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4108181/ https://ncbi.nlm.nih.gov/pubmed/24977643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5003234 |
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