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Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases
Targeting of cryptic binding sites represents an attractive but underexplored approach to modulating protein function with small molecules. Using the dimeric protease (Pr) from Kaposi’s sarcoma-associated herpes-virus (KSHV) as a model system, we sought to dissect a putative allosteric network linki...
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| Veröffentlicht in: | J Am Chem Soc |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6089631/ https://ncbi.nlm.nih.gov/pubmed/28759216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b04030 |
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