Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene

Adoptive transfer of donor-derived T lymphocytes expressing a safety switch may promote immune reconstitution in patients undergoing haploidentical hematopoietic stem cell transplant (haplo-HSCT) without the risk for uncontrolled graft versus host disease (GvHD). Thus, patients who develop GvHD afte...

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Xiaoou, Di Stasi, Antonio, Tey, Siok-Keen, Krance, Robert A., Martinez, Caridad, Leung, Kathryn S., Durett, April G., Wu, Meng-Fen, Liu, Hao, Leen, Ann M., Savoldo, Barbara, Lin, Yu-Feng, Grilley, Bambi J., Gee, Adrian P., Spencer, David M., Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K., Dotti, Gianpietro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2014
Schlagworte:
Clinical Trials and Observations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064331/
https://ncbi.nlm.nih.gov/pubmed/24753538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-551671
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