Calicheamicin-DNA complexes: warhead alignment and saccharide recognition of the minor groove.

The solution structures of calicheamicin gamma 1I, its cycloaromatized analog (calicheamicin epsilon), and its aryl tetrasaccharide complexed to a common DNA hairpin duplex have been determined by NMR and distance-refined molecular dynamics computations. Sequence specificity is associated with carbo...

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Bibliographic Details
Main Authors: Ikemoto, N, Kumar, R A, Ling, T T, Ellestad, G A, Danishefsky, S J, Patel, D J
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC40640/
https://ncbi.nlm.nih.gov/pubmed/7479829
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