Calicheamicin-DNA complexes: warhead alignment and saccharide recognition of the minor groove.

The solution structures of calicheamicin gamma 1I, its cycloaromatized analog (calicheamicin epsilon), and its aryl tetrasaccharide complexed to a common DNA hairpin duplex have been determined by NMR and distance-refined molecular dynamics computations. Sequence specificity is associated with carbo...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ikemoto, N, Kumar, R A, Ling, T T, Ellestad, G A, Danishefsky, S J, Patel, D J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40640/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479829/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.23.10506
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