Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)

Despite genetic evidence establishing angiopoietin-1 (Ang-1) as an essential regulator of vascular development, the molecular mechanisms underlying Ang-1 function are almost completely uncharacterized. In this report, we demonstrate that Ang-1, via Akt activation, is a potent inhibitor of the forkhe...

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Bibliografiske detaljer
Main Authors: Daly, Christopher, Wong, Vivian, Burova, Elena, Wei, Yi, Zabski, Stephanie, Griffiths, Jennifer, Lai, Ka-Man, Lin, Hsin Chieh, Ioffe, Ella, Yancopoulos, George D., Rudge, John S.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2004
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC406295/
https://ncbi.nlm.nih.gov/pubmed/15132996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1189704
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