Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells

Angiopoietin (Ang)-2, a context-dependent agonist/antagonist for the vascular-specific Tie2 receptor, is highly expressed by endothelial cells at sites of normal and pathologic angiogenesis. One prevailing model suggests that in these settings, Ang-2 acts as an autocrine Tie2 blocker, inhibiting the...

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Detalhes bibliográficos
Main Authors: Daly, Christopher, Pasnikowski, Elizabeth, Burova, Elena, Wong, Vivian, Aldrich, Thomas H., Griffiths, Jennifer, Ioffe, Ella, Daly, Thomas J., Fandl, James P., Papadopoulos, Nick, McDonald, Donald M., Thurston, Gavin, Yancopoulos, George D., Rudge, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592534/
https://ncbi.nlm.nih.gov/pubmed/17030814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607538103
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