Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor

Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2) are ligands for Tie2, an endothelial-specific receptor tyrosine kinase that is an essential regulator of angiogenesis. Here we report the identification, via expression cloning, of thrombomodulin (TM) as another receptor for Ang1 and Ang2. Thrombomodul...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Daly, Christopher, Qian, Xiaozhong, Castanaro, Carla, Pasnikowski, Elizabeth, Jiang, Xiabo, Thomson, Benjamin R., Quaggin, Susan E., Papadopoulos, Nicholas, Wei, Yang, Rudge, John S., Thurston, Gavin, Yancopoulos, George D., Davis, Samuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765006/
https://ncbi.nlm.nih.gov/pubmed/29323190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18912-8
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