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Thrombomodulin binding selects the catalytically active form of thrombin
Human α-thrombin is a serine protease with dual functions. Thrombin acts as a procoagulant, cleaving fibrinogen to make the fibrin clot, but when bound to thrombomodulin (TM), it acts as an anticoagulant, cleaving protein C. A minimal TM fragment consisting of the 4(th), 5(th), and most of the 6(th)...
Sparad:
| I publikationen: | Biochemistry |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4697735/ https://ncbi.nlm.nih.gov/pubmed/26468766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00825 |
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