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Thrombomodulin binding selects the catalytically active form of thrombin

Human α-thrombin is a serine protease with dual functions. Thrombin acts as a procoagulant, cleaving fibrinogen to make the fibrin clot, but when bound to thrombomodulin (TM), it acts as an anticoagulant, cleaving protein C. A minimal TM fragment consisting of the 4(th), 5(th), and most of the 6(th)...

Полное описание

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Библиографические подробности
Опубликовано в: :Biochemistry
Главные авторы: Handley, Lindsey D., Treuheit, Nicholas A., Venkatesh, Varun J., Komives, Elizabeth A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697735/
https://ncbi.nlm.nih.gov/pubmed/26468766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00825
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