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Mutations in the fourth EGF-like domain affect thrombomodulin-induced changes in the active site of thrombin
A number of alanine and more conservative mutants of residues in the fourth domain of thrombomodulin (TM) were prepared and assayed for protein C activation and for thrombin binding. Several of the alanine mutations appeared to cause misfolding or structural defects as assessed by poor expression an...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630536/ https://ncbi.nlm.nih.gov/pubmed/18803401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8008278 |
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