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Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation
Angiopoietin-2 (ANG2) regulates blood vessel remodeling in many pathological conditions through differential effects on Tie2 signaling. While ANG2 competes with ANG1 to inhibit Tie2, it can paradoxically also promote Tie2 phosphorylation (p-Tie2). A related paradox is that both inactivation and over...
में बचाया:
| में प्रकाशित: | J Clin Invest |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Society for Clinical Investigation
2016
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5004955/ https://ncbi.nlm.nih.gov/pubmed/27548529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84871 |
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