Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

Angiopoietin-2 (ANG2) regulates blood vessel remodeling in many pathological conditions through differential effects on Tie2 signaling. While ANG2 competes with ANG1 to inhibit Tie2, it can paradoxically also promote Tie2 phosphorylation (p-Tie2). A related paradox is that both inactivation and over...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kim, Minah, Allen, Breanna, Korhonen, Emilia A., Nitschké, Maximilian, Yang, Hee Won, Baluk, Peter, Saharinen, Pipsa, Alitalo, Kari, Daly, Christopher, Thurston, Gavin, McDonald, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004955/
https://ncbi.nlm.nih.gov/pubmed/27548529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84871
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