Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts

BACKGROUND: Carbonic anhydrase IX (CA IX) is a transmembrane enzyme that is present in many types of solid tumors. Expression of CA IX is driven predominantly by the hypoxia-inducible factor (HIF) pathway and helps to maintain intracellular pH homeostasis under hypoxic conditions, resulting in acidi...

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Bibliografiske detaljer
Main Authors: Ditte, Zuzana, Ditte, Peter, Labudova, Martina, Simko, Veronika, Iuliano, Filippo, Zatovicova, Miriam, Csaderova, Lucia, Pastorekova, Silvia, Pastorek, Jaromir
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061103/
https://ncbi.nlm.nih.gov/pubmed/24886661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-358
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