Prevalence of the TP53 p.R337H Mutation in Breast Cancer Patients in Brazil

Germline TP53 mutations predispose individuals to multiple cancers and are associated with Li-Fraumeni/Li-Fraumeni-Like Syndromes (LFS/LFL). The founder mutation TP53 p.R337H is detected in 0.3% of the general population in southern Brazil. This mutation is associated with an increased risk of child...

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Autori principali: Giacomazzi, Juliana, Graudenz, Marcia S., Osorio, Cynthia A. B. T., Koehler-Santos, Patricia, Palmero, Edenir I., Zagonel-Oliveira, Marcelo, Michelli, Rodrigo A. D., Neto, Cristovam Scapulatempo, Fernandes, Gabriela C., Achatz, Maria Isabel W. S., Martel-Planche, Ghyslaine, Soares, Fernando A., Caleffi, Maira, Goldim, José Roberto, Hainaut, Pierre, Camey, Suzi A., Ashton-Prolla, Patricia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061038/
https://ncbi.nlm.nih.gov/pubmed/24936644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099893
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