Increased oxidative damage in carriers of the germline TP53 p.R337H mutation.

Germline mutations in TP53 are the underlying defect of Li-Fraumeni Syndrome (LFS) and Li-Fraumeni-like (LFL) Syndrome, autosomal dominant disorders characterized by predisposition to multiple early onset cancers. In Brazil, a variant form of LFS/LFL is commonly detected because of the high prevalen...

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Main Authors: Gabriel S Macedo, Leonardo Lisbôa da Motta, Juliana Giacomazzi, Cristina B O Netto, Vanusa Manfredini, Camila S Vanzin, Carmen Regla Vargas, Pierre Hainaut, Fábio Klamt, Patricia Ashton-Prolla
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2012-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC3467233?pdf=render
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