Increased Oxidative Damage in Carriers of the Germline TP53 p.R337H Mutation

Germline mutations in TP53 are the underlying defect of Li-Fraumeni Syndrome (LFS) and Li-Fraumeni-like (LFL) Syndrome, autosomal dominant disorders characterized by predisposition to multiple early onset cancers. In Brazil, a variant form of LFS/LFL is commonly detected because of the high prevalen...

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Autori principali: Macedo, Gabriel S., Lisbôa da Motta, Leonardo, Giacomazzi, Juliana, Netto, Cristina B. O., Manfredini, Vanusa, S.Vanzin, Camila, Vargas, Carmen Regla, Hainaut, Pierre, Klamt, Fábio, Ashton-Prolla, Patricia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467233/
https://ncbi.nlm.nih.gov/pubmed/23056559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047010
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