Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures

Germline TP53 mutations predispose to multiple cancers defining Li-Fraumeni/Li-Fraumeni-like syndrome (LFS/LFL), a disease with large individual disparities in cancer profiles and age of onset. G-quadruplexes (G4s) are secondary structural motifs occurring in guanine tracks, with regulatory effects...

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Detalhes bibliográficos
Main Authors: Sagne, Charlotte, Marcel, Virginie, Bota, Maria, Martel-Planche, Ghyslaine, Nobrega, Amanda, Palmero, Edenir Inêz, Perriaud, Laury, Boniol, Mathieu, Vagner, Stephan, Cox, David G., Chan, Chang S., Mergny, Jean-Louis, Olivier, Magali, Ashton-Prolla, Patricia, Hall, Janet, Hainaut, Pierre, Achatz, Maria Isabel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977145/
https://ncbi.nlm.nih.gov/pubmed/24336192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt381
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