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Potent and Orally Efficacious Bisthiazole-Based Histone Deacetylase Inhibitors
[Image: see text] Inspired by the thiazole–thiazoline cap group in natural product largazole, a series of structurally simplified bisthiazole-based histone deacetylase inhibitors were prepared and evaluated. Compound 8f was evaluated in vivo in an experimental autoimmune encephalomyelitis (EAE) mode...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4060935/ https://ncbi.nlm.nih.gov/pubmed/24944733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400470s |
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