Acyl-Coenzyme A:cholesterol Acyltransferase 1: Significance of Single Nucleotide Polymorphism at Residue 526 and Role of Proline 347 near the Fifth Transmembrane Domain

Acyl-Coenzyme A:cholesterol Acyltransferases (ACATs), members of the membrane bound O-acyltransferase (MBOAT) family, catalyze the conversion of cholesterol to cholesteryl esters. Mammals contain two isoenzymes ACAT1 and ACAT2. Both enzymes are drug targets for treating human diseases. ACAT1 is pres...

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Bibliografiska uppgifter
Huvudupphovsmän: Huang, Li-Hao, Nishi, Koji, Li, Song, Ho, Thomas, Dong, Ruhong, Chang, Catherine C.Y., Chang, Ta-Yuan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060832/
https://ncbi.nlm.nih.gov/pubmed/24517390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12739
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