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Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes

We investigated the mechanism of spontaneous cholesterol efflux induced by acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibition, and how an alteration of cholesterol metabolism in macrophages impacts on that in HepG2 cells. Oleic acid anilide (OAA), a known ACAT inhibitor reduced lipid stor...

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Bibliografske podrobnosti
Main Authors: An, Sojin, Jang, Young-Soon, Park, Ji-Seon, Kwon, Byoung-Mog, Paik, Young-Ki, Jeong, Tae-Sook
Format: Artigo
Jezik:Inglês
Izdano: Korean Society of Medical Biochemistry and Molecular Biology 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679275/
https://ncbi.nlm.nih.gov/pubmed/18779653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2008.40.4.407
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